吴欢生(1988.3—),男,汉族,江西余干人,博士,讲师。2019年博士毕业于浙江大学预防兽医学专业,获农学博士学位。2019年6月入职江西农业大学,现为动物科学技术学院预防兽医教研室成员。主要从事预防兽医学的教学和科研工作,主攻方向为动物病毒的致病分子机理研究,2020年获江西农业大学“未来之星”。先后主持国家自然科学基金1项,江西省自然基金1项,江西省教育厅项目1项。以第一作者或通讯作者先后发表学术论文17篇,其中SCI收录15篇,A类学报2篇,申请国家发明专利2项,授权实用新型专利2项。Viruses, Poultry Science等SCI杂志审稿人。邮箱:huanswu@jxau.edu.cn,联系电话:18458219873(微信同号)。
一、教育经历
2012.09-2019.03 浙江大学,兽医学,农学博士
2008.09-2012.06 江西农业大学,动物医学,农学学士
二、工作经历
2019.06至今 江西农业大学 讲师
三、代表性研究论文
(1) Xifeng Hu, Zheng Chen, Xiangdong Wu, Zhen Ding, Yu Huang, Qiuling Fu, Zhen Chen, Huansheng Wu. Phosphorylation of VP1 Mediated by CDK1-Cyclin B1 Facilitates Infectious Bursal Disease Virus Replication[J]. Journal of Virology, 2023, 97(1): 1-20. (通讯作者)
(2) Xifeng Hu, Zheng Chen, Xiaomei Wang, Qiuling Fu, Zhen Chen, Yu Huang, Huansheng Wu. PRMT5 facilitates infectious bursal disease virus replication through arginine methylation of VP1[J]. Journal of Virology, 2023, 98(2): 1-18. (通讯作者)
(3) Huansheng Wu*, Hui Yang*, Gang Ji, Tuyuan Zheng, Yina Zhang, Tingjuan Deng, Xiaojuan Zheng, Jiyong Zhou, Boli Hu.SUMO1 Modification Facilitates Avibirnavirus Replication by Stabilizing Polymerase VP1[J]. Journal of Virology, 2019, 93(10): e02227-18. (第一作者)
(4) Huansheng Wu*, Liuyuan Shi, Yina Zhang, Xiran Peng, Tuyuan Zheng, Yahui Li, Boli Hu, Xiaojuan Zheng, Jiyong Zhou. Ubiquitination Is Essential for Avibirnavirus Replication by Supporting VP1 Polymerase Activity[J]. Journal of Virology, 2019, 93(3): e01899-18. (第一作者)
(5) Zheng Chen, Xifeng Hu, Xiangdong Wu, Yu Li, Zhen Ding, Qinghua Zeng, Tong Wan, Jingyi Yin, Huansheng Wu#. Development and Primary Application of an Indirect ELISA Based on Rep Protein to Analyze Antibodies against Porcine Cocirvirus-like Virus (PCLV) [J]. Viruses-Basel, 2022,1398): 1-10. (通讯作者)
(6) Xifeng Hu, Zheng Chen, Xiangdong Wu, Zhen Ding, Qinghua Zeng, Huansheng Wu#. An Improved, Dual-Direction,Promoter-Driven, Reverse Genetics System for the Infectious Bursal Disease Virus (IBDV) [J]. Viruses-Basel, 2022,14(1396): 2-13. (通讯作者)
(7) Xifeng Hu, Huansheng Wu#. SUMOylation of optineurin is critical for inhibiting interferon b production[J]. Biochemical and Biophysical Research Communications, 2022, 07(44): 1-7. (通讯作者)
(8) Xifeng Hu, Zheng Chen, Yu Li, Zhen Ding, Qinghua Zeng, Tong Wan, Huansheng Wu#. Detection of Porcine Circovirus 1/2/3 and Genetic Analysis of Porcine Circovirus 2 in Wild Boar from Jiangxi Province of China [J]. Animals, 2022, 12(2021):1-11. (通讯作者)
(9) Huansheng Wu*, Chengyao Hou*, Zhiru Wang, Puyan Meng, Hongying Chen, Huabin Cao First complete genomic sequence analysis of porcine circovirus type 4 (PCV4) in wild boars [J]. Veterinary Microbiology, 2022, 273(109547): 1-6. (通讯作者)
(10) Xifeng Hu, Xiangdong Wu, Meijia Xue, Yiting Chen, Beiyi Zhou, Tong Wan, Hongnan You, Huansheng Wu#. Chicken TAX1BP1 suppresses type I interferon production via degrading chicken MAVS and facilitates infectious bursal diseases virus replication[J]. Developmental and Comparative Immunology,2022, 135(104490): 1-8. (通讯作者)
(11) Yu Li, Ning Jinag, Yaqing Mao, Wenbo Zhang, Jing Xiao, Xiangdong Wu#, Huansheng Wu#. Chicken optineurin suppresses MDA5-mediated interferon β production[J]. Poultry Science, 2020, 10(1): 9-11. (通讯作者)
(12) Xifeng Hu, Xiangdong Wu, Zhen Ding. Zhen Cheng, Huansheng Wu#. Characterization and functional analysis of chicken dsRNA binding protein hnRNPU[J]. Developmental and comparative immunology, 2022, 148(104510):1-10. (通讯作者)
(13) Xifeng Hu, Zheng Chen, Deping Song, Yu Li, Zhen Ding, Xiangdong Wu, Hongnan You, Huansheng Wu. Frequency detection of porcine circovirus-like virus in pigs with porcine respiratory disease[J]. Veterinary Microbiology, 2022, 275(109581):1-11. (通讯作者)
(14) Xifeng Hu, Zhen Ding, Yu Li, Zheng Chen, Huansheng Wu. Serum investigations of antibodies against porcine circovirus 4 Rep and Cap protein in Jiangxi Province, China[J]. Veterinary Microbiology, 2022, 12(34):1-9. (通讯作者)
(15) 吴欢生*, 康冬柳, 胡爱明, 刘远超, 李家奎, 瞿明仁, 欧阳克惠, 曹华斌. 江西省急性腹泻牛源的BHoVJX株全基因组序列测定及其分析[J].中国预防兽医学报, 2021.43(07): 772-776. (第一作者)
(16) 吴欢生*, 康冬柳, 胡爱明, 刘远超, 李家奎, 瞿明仁, 欧阳克惠, 曹华斌. 野猪源猪圆环病毒4型的发现及其Cap基因序列分析[J].中国预防兽医学报, 2022.44(10): 1106-1110. (第一作者)
(17) Xifeng Hu, Xiangdong Wu, Zheng Chen, Huansheng Wu. Chicken PRMT1 promotes infectious bursal disease virus replication via suppressing IFN-β production[J]. Developmental and Comparative Immunology,2023, 141(104628): 1-12. (通讯作者)
四、主持科研项目
[1] 国家自然科学基金项目:解析周期蛋白依赖性激酶CDK1 磷酸化传染性法氏囊炎病(IBDV)VP1 蛋白的分子机制(32002288),2021.01-2023.12,主持,在研;
[2] 江西省自然科学基金项目:选择性自噬受体optineurin 靶向VP1 抑制传染性法氏囊炎病毒复制机制研究(90191087907),2020.12-2022.12,主持,结题;
[3] 江西省教育厅科技计划项目:TAX1BP1 促进禽双RNA 病毒复制机制研究(GJJ190213),2019.12-2021.12,主持,结题。
五、申请或授权国家专利
(1)吴欢生,邬向东,胡西风;基于CRISPR-Cas9敲除PRMT1基因DF-1细胞株的构建及其应用,发明专利,申请。
(2)吴欢生,邬向东,游洪南,胡西风;PRMT5基因敲除DF-1细胞株的构建及其应用,发明专利,申请。
(3)吴欢生,胡西凤,李钰,张昊;一种畜牧兽医专用连续灌药器,实用新型,授权。
(4)吴欢生,李钰,胡西凤,王旺林;一种兽医用夹持装置,实用新型,授权。