一、基本信息
庄煜，1988年2月生，男，汉族，江西赣州人，博士、博士后，副教授，江西农业大学硕士研究生导师、江西农业大学“未来之星”。国家执业兽医师，兼任中国畜牧兽医学会兽医内科与临床诊疗学分会、影像学分会理事，江西省遂川县肉鸽产业科技小院及上栗兔产业科技小院指导专家。主要从事中兽药与天然活性成分功能鉴定及产品研发、畜禽营养代谢与中毒疾病的教学科研工作。
二、科研项目概况
主持国家自然科学基金、江西省杰出青年基金、中国博士后科学基金等省部级以上项目10余项；作为核心成员参与国家自然科学基金面上项目等多项。以第一或通讯作者发表SCI论文20余篇，获国家发明专利6项。研究方向聚焦蛋鸡脂肪肝出血综合征的分子机制与天然产物干预、霉菌毒素及环境污染物致肠道损伤的调控策略，在脂噬、线粒体功能、自噬与焦亡等前沿领域取得系列进展。
三、教育经历（按时间倒序）
2013.09-2016.06：江西农业大学，动物科学技术学院，博士生
2010.09-2013.06：江西农业大学，动物科学技术学院，硕士研究生
2006.09-2010.06：江西农业大学，动物科学技术学院，学士
四、工作经历（按时间倒序）
2019.07-至今：江西农业大学，副教授
2016.07-2019.06：湖南师范大学，博士后
五、代表性研究成果和学术奖励情况
（一）代表性 SCI 学术论文（近五年优先，按时间降序）
1.Wenqi Zeng, Lingling Yang, Chun Zeng, Xinyi Cheng, Panpan Cao, Chenghong Xing, Caiying Zhang, Huabin Cao, Xiaoquan Guo, Guoliang Hu, Yu Zhuang. MicroR-15b-5p targets JAK2/STAT3 signaling pathway to regulate glucose and lipid metabolism in primary chicken hepatocytes. Poult Sci. 2026 Mar;105(3):106390.
2.Panpan, Cao., Jinyan, Chen., Chun, Zeng., Yang, Hu., Jianyun, Yuan., Xiaoquan, Guo., Huabin, Cao., Caiying, Zhang., Yu, Zhuang*, Guoliang, Hu*. SIRT3-mediated mitochondrial fatty acid oxidation protects against hepatic lipid deposition in fatty liver hemorrhagic syndrome. Poult Sci, 2026 105(7), 106901.
3.Jiayi Ding, Chun Zeng, Yang Hu, Xinyi Cheng, Jinyan Chen, Huabin Cao,Xiaoquan Guo, Caiying Zhang, Guoliang Hu, Yu Zhuang. Itaconic acid regulates endoplasmic reticulum stress and apoptosis via SERCA2 to alleviate ovarian dysfunction in laying hens with fatty liver hemorrhage syndrome. The Journal of Nutritional Biochemistry. 2026;137:109985.
4.Panpan Cao , Jiazhen Wei , Xinyi Cheng , Yu Zhuang , Junrong Luo , Huabin Cao , Caiying Zhang , Xiaoquan Guo, Guoliang Hu. Baicalin-copper complex alleviates intestinal damage in avian pathogenic Escherichia coli-infected chicks by targeting the AKT/NF-κB pathway. Frontiers in Veterinary Science. 2025;12:1648736.
5.Chun, Zeng, Zhenyu, Zou, Xinyi, Cheng, Yang, Hu, Yu, Huang, Zhongtao, Li., Xiaoquan, Guo., Huabin Cao, Caiying, Zhang, Guoliang, Hu*, Yu, Zhuang*. TFEB Dysfunction Mediates Lysosomal Membrane Permeabilization-Induced Pyroptosis in Deoxynivalenol-Exposed Intestinal Epithelium. J Agric Food Chem, 2025, 73(44), 28430-28444.
6.Zhenyu Zou, Xinyi Cheng, Jinyan Chen, Chenghong Xing, Caiying Zhang, Xiaoquan Guo, Huabing Cao, Guoliang. Hu*, Zhuang Yu*. Curcumin alleviates atrazine-induced nephrotoxicity by enhancing mitophagy through PINK1/Parkin signaling pathway in mice. Ecotoxicol Environ Saf, 295(undefined), 2025, 118118.
7.Jianyun Yuan, Ke Zhang, Lingling Yang, Xinyi Cheng, Jinyan Chen, Xiaoquan Guo, Huabin Cao, Caiying Zhang, Chenghong Xing, Guoliang Hu*, Yu Zhuang*. Luteolin attenuates LPS-induced damage in IPEC-J2 cells by enhancing mitophagy via AMPK signaling pathway activation. Front Nutr, 2025, 12(undefined), 1552890.
8.Sufang Cheng, Xin Liu, Suzhen Cheng, Shuwei Zhang, Ping liu, Yu Zhuang and Guoliang Hu*, 2025. The research mechanism of the gut-liver axis in non-alcoholic fatty liver disease. Pak Vet J, 45(4): 1524-1531.
9.Xinyi Cheng, Yang Hu, Xiaoqing Yu, Jinyan Chen, Xiaoquan Guo, Huabin Cao, Guoliang Hu*, Yu Zhuang*. Sodium Butyrate Alleviates Free Fatty Acid-Induced Steatosis in Primary Chicken Hepatocytes via Regulating the ROS/GPX4/Ferroptosis Pathway. Antioxidants (Basel). 2024 Jan 23;13(2):140.
10.Jiahua Liang, Jinyan Chen, Lingling Yang, Dan Wu, Lijuan Xiong, Xiaoquan Guo, Huabin Cao, Caiying Zhang, Guoliang Hu*, Yu Zhuang*. Curcumin alleviates atrazine-induced cardiotoxicity by inhibiting endoplasmic reticulum stress-mediated apoptosis in mice through ATF6/Chop/Bcl-2 signaling pathway. Biomedicine & Pharmacotherapy, 2024;171:116205.
11.Xinyi Cheng, Jinyan Chen, Xiaoquan Guo, Huabin Cao, Caiying Zhang, Guoliang, Hu*, Yu Zhuang*. Disrupting the gut microbiota/metabolites axis by Di-(2-ethylhexyl) phthalate drives intestinal inflammation via AhR/NF-κB pathway in mice. Environmental pollution, 2024;343:123232.
12.Xinyi Cheng, Yang Hu, Jun Kuang, Xiaoquan Guo, Huabin Cao, Huansheng Wu, Guoliang Hu*, Yu Zhuang*. Berberine alleviates high-energy and low-protein diet-induced fatty liver hemorrhagic syndrome in laying hens: insights from microbiome and metabolomics. Poultry Science. 2024;103(8):103968.
13.Jiayi Ding, Jiuyue Liu, Jinyan Chen, Xinyi Cheng, Huabin Cao, Xiaoquan Guo, Guoliang Hu, Yu Zhuang*. Sodium butyrate alleviates free fatty acid-induced steatosis in primary chicken hepatocytes via the AMPK/PPARα pathway. Poultry Science. 2024;103(4):103482.
14.Jiayi Ding, Xinyi Cheng, Chun Zeng, Qintao Zhao, Chenghong Xing, Caiying Zhang, Huabin Cao,Xiaoquan Guo, Guoliang Hu, Yu Zhuang*. Aflatoxin B1 Promotes Pyroptosis in IPEC-J2 Cells by Disrupting Mitochondrial Dynamics through the AMPK/NLRP3 Pathway. Journal of Agricultural and Food Chemistry. 2024;72(50):28093-28108.
15.Chang Wang, Yitian Yang, Jinyan Chen, Xueyan Dai, Chenghong Xing, Caiying Zhang, Huabin Cao, Xiaoquan Guo, Guoliang Hu*, Yu Zhuang*. Berberine Protects against High-Energy and Low-Protein Diet-Induced Hepatic Steatosis: Modulation of Gut Microbiota and Bile Acid Metabolism in Laying Hens. International journal of molecular, 2023;24(24):17304.
16.Chang Wang, Xueyan Dai, Chenghong Xing, Caiying Zhang, Huabin Cao, Xiaoquan Guo, Ping Liu, Fan Yang, Yu Zhuang*, Guoliang Hu*. Hexavalent-Chromium-Induced Disruption of Mitochondrial Dynamics and Apoptosis in the Liver via the AMPK-PGC-1α Pathway in Ducks. International journal of molecular, 2023;24(24):17241.
17.Jiahua Liang, Ying Zhou, Xinyi Cheng, Jiaqi Chen, Huabin Cao, Xiaoquan Guo, Caiying Zhang, Yu Zhuang*, Guoliang Hu*. Baicalin Attenuates H2O2-Induced Oxidative Stress by Regulating the AMPK/Nrf2 Signaling Pathway in IPEC-J2 Cells. International journal of molecular, 2023;24(11):9435.
18.Xinyi Cheng, Jiahua Liang, Dan Wu, Xiaoquan Guo, Huabin Cao, Caiying Zhang, Ping Liu, Ruiming Hu, Guoliang Hu*, Yu Zhuang*. Blunting ROS/TRPML1 pathway protects AFB1-induced porcine intestinal epithelial cells apoptosis by restoring impaired autophagic flux. Ecotoxicology and Environmental Safety, 2023;257:114942.
（二）发明专利
1.胡国良、庄煜、幸程鸿、蒲文静、程鑫怡、曹盼盼、黎钟涛、袁捡云、吴珂，蛋鸡脂肪肝预防饲养管理系统 V1.0，专利号：2025SR0386569
2.胡国良、庄煜、幸程鸿、蒲文静、程鑫怡、曹盼盼、黎钟涛、袁捡云、吴珂，蛋鸡脂肪肝出血综合征的诊断系统 V1.0，专利号：2025SR0386664
3.HU Guoliang, ZHUANG Yu, CHENG Xinyi, XING Chenghong, GUO Xiaoquan, CAO Huabin, LIU Ping，MONOCLONAL ANTIBODY AGAINST CHICKEN TIPE1 GENE AND PREPARATION METHOD AND APPLICATIONTHEREOF，专利号：2025/00827
4.庄煜、胡国良、胡杨、程鑫怡、幸程鸿，一种lncLRFIF及其在制备治疗蛋鸡脂肪肝出血综合征的药物中的应用，专利号：ZL 2025 1 1068468.9。
5.胡国良、庄煜、曹盼盼、程鑫怡、曾春、胡杨，车前草多糖的制备及其在制备防治蛋鸡脂肪肝出血综合征的药物中的应用，专利号：ZL 2025 1 0023169.7。
6.胡国良、幸程鸿、曹华斌、郭小权、张彩英、庄煜、杨帆、杨倚天、陈毅燕， 一种含盐酸小檗碱的饲料添加剂、制备方法及其在蛋鸡脂肪肝防治中的应用[P]. 江西省: CN113100329B。
（三）学术奖励情况
六、主持或参加科研项目及人才计划项目情况（时间倒序）
1.国家自然科学基金委员会，LncRNA-1092.1/miR-15b-5p/PLIN2轴在蛋鸡脂肪肝出血综合征肝脏脂噬障碍中的作用（32460910），2025-01至2023-12，32万，主持，在研
2.江西省杰出基金项目，江西省自然科学基金-杰出青年基金项目，SERAC2 介导的钙稳态失衡在蛋鸡脂肪肝出血综合征卵巢早衰的作用及衣康酸的保护机制（20252BAC220046），2025.06至2028-06，30万，主持，在研
3.江西省自然科学基金项目，呕吐毒素通过TRPML1介导细胞自噬调控巨噬细胞极化致仔猪肠道损伤机制的研究（20224BAB215053），2022.01~2025.12，10.0万，主持，结题
4.横向项目，基于巨噬细胞极化探讨黄芩苷对禽大肠杆菌致雏鸡肠炎的保护机制研究，2021.01~2022.01，55.0万，主持，结题
5.江西省教育厅科技计划项目：SESN2介导自噬对热应激诱导猪肠道损伤的作用机制研究（GJJ190221），2019.12-2021.12，3万，主持，结题
6.中国博士后科学基金：SESN2介导线粒体自噬在猪肠上皮细胞损伤修复机制研究（2017M612562），2017.1-2019.6，5万，主持，结题
7.国家自然科学基金委员会，面上项目，32373090，MiR-15b-5p通过靶向SIRT3调节线粒体能量代谢在蛋鸡脂肪肝出血综合征中的调控机制，2024-01至2027-12，50万元，在研，参与，第二
8.国家自然科学基金委员会，面上项目，31871469，天然免疫信号调控肠道上皮细胞脱落的分子机制研究，2019-01至2020-12，25万元，结题，参与，第二
